Discovering the etiology of complex traits with in vitro genetics
We bring together genetics, stem cell biology, organoids, and single cell technologies to characterize the molecular basis of disease phenotypes and drug response.
What We Do
Understanding Complex Biology
We use our in vitro genetics platform to elucidate molecular mechanisms of action and to find and validate novel drug targets.
In Vitro Genetics
Genomewide screens for quantitative trait loci that modulate drug response phenotypes, combining high throughput screening with genetically diverse stem cells.
Stem Cell Models
A proprietary panel of over 1,000 mouse ES cell lines from Diversity Outbred mice, differentiated to therapeutically relevant cell types for phenotypic screening.
Target Discovery
Genetically validated targets double the likelihood of a successful drug discovery program. We identify causal mediators and prioritize compounds for clinical studies.
Current Programs
Research Focus Areas
Neuroscience
Genetic screens for genes that modify cell swelling in astrocytes (cytotoxic edema), and eQTL screens across cerebral organoids for mechanistic studies in autism and other psychiatric and neurodevelopmental disorders.
Preclinical Pharmacology
Evaluating drug action across genetic diversity in preclinical studies, when molecules have druglike properties but remain available for chemical modification. Better understanding of mechanism helps prioritize candidates.
Environmental Toxicology
Finding genes that modulate susceptibility to toxicants drives development of more predictive toxicity assays. SBIR funded projects using cerebral organoids to identify modifiers of developmental neurotoxicants.
Capabilities
Advanced Analytical Technologies
We deploy a comprehensive suite of genomic and functional assays for both 2D and 3D cellular models, from genome-scale transcriptomics to custom high-throughput imaging solutions.
Partner With Us
We partner with pharmaceutical companies, biotechnology companies, and academic labs to conduct leading edge research programs in preclinical pharmacology and stem cell sciences.